一、录取要求：

1.本实验室拟招收生物学或临床检验诊断学专业硕士研究生6名；

2.总分数、单科须过国家A类分数线；

3.来自“985”、“211”等高校的优秀考生，同等条件下优先录取；

4.通过国家英语六级的优秀考生，同等条件下优先调剂。

二、待遇

1.除学校提供的生活补贴外，导师根据学生表现每月提供额外的劳务补贴。

2.为研究生提供良好的生活条件，国家和本校通过设立奖学金、助学金、助学贷款、三助岗位、绿色通道等制度，建立多元奖助体系。目前已设的奖学金如下：

国家奖学金：20000元。

台湾光华教育基金会设立的光华奖学金：我校是浙江省属院校中唯一设立该奖学金的学校。

中国科学院毛江森院士在我校设立的毛江森奖学金和助学金:特等奖学金2万元,奖学金5000元，助学金2000元。

生物药械豪森药业奖学金和助学金：特等奖5000元，一等奖2000元，二等奖1000元，三等奖500元。

康泉奖学金：特等奖5000元。

东瓯奖学金、迪安奖学金等。

三、实验室基本情况

本实验室近20年来致力于线粒体分子遗传学和母性遗传病致病机制的研究,主要方向有耳聋遗传、Leber遗传性视神经病变、原发性高血压,tRNA碱基修饰机制及其在线粒体疾病发病中的作用等。课题组已在国内外著名刊物上发表论文100多篇，SCI收录论文80余篇，累计影响因子300余分。导师管敏鑫教授作为国际线粒体分子遗传学和母性遗传病领域知名专家，国际该领域领军人物之一，目前主持及参与国家“973”计划项目，十二五支撑项目，国家自然科学基金重点项目等。热诚欢迎对线粒体生物医学研究感兴趣的研究生加入我们的研究团队！

四、导师简介：

管敏鑫教授:

（一）基本信息：

1962年生于浙江省乐清市

1979.9-1983.7杭州大学（现浙江大学）生物系本科

1983.8-1989.9浙江图书馆馆员

1989.9-1993.7澳大利亚国立大学（ANU）生物化学与分子生物学博士研究生

1993.8-1996.7加州理工学院（Caltech）人类分子遗传学ResearchFellow

1996.8-1999.7加州理工学院生物系SeniorResearchFellow

1999.8-2011.9辛辛那提大学儿童医院医学中心人类遗传学助理教授、副教授、教授

2011.1-2013.11浙江大学生命科学学院院长

2011.1-至今浙江大学生命科学学院教授、博导

（二）学术兼职

温州医学院生命科学学院院长,教授(2004-2010)

中国人民解放军总医院/军医进修学院客座教授（2002-至今）

美国辛辛那提大学儿童医院医学中心客座教授(2011.10-至今)

浙江省高等学校特聘教授(2006-2009)

浙江省医学遗传学重点实验室学术委员会主任（2005-至今）

第四届亚洲线粒体研究与医学学会（ASMRM）主席（2011-至今）

（三）奖励荣誉

国家“千人计划”入选者(2012)

浙江省特聘专家(2010)

国务院政府特殊津贴(2010)

浙江省有突出贡献中青年专家（2009）

浙江省优秀留学回国人员（2008）

首批浙江省卫生高层次创新人才（2007）

浙江省高等学校特聘教授（2006年）

浙江省“新世纪151人才工程”第一层次培养人员（2006）

国家自然科学基金海外及港澳学者合作研究基金(2006)

（四）主持项目

1.国家重点基础研究发展计划（973计划）:单基因遗传性聋病的分子机制研究,2014.1-2018.12

2.国家自然科学基金重点项目：核修饰基因调控母系遗传性耳聋发病机制及听觉功能重建的策略研究,2014.1-2017.12

3.十二五支撑项目：Leber遗传性视神经病变的分子诊断和治疗研究,2012.1-2015.12

（五）研究成果

2009年度《母系遗传药物性耳聋致病机制研究及干预》中华医学科技奖,二等奖

2009年度《母系遗传药物性耳聋致病机制的研究》浙江省科学技术奖,一等奖

2008年度《聋病发生的分子机制与防控预警的系统研究》国家科技进步奖,二等奖

2007年度《Leber氏遗传性视神经萎缩遗传性状研究》，国家科技进步奖,二等奖

（六）代表性论文
耳聋遗传
Guan, M.X., Fischel-Ghodsian,N. and Attardi,G. (1996) Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation.Hum. Mol. Genet. 5:963-972.
Guan, M.X.,Enriquez,J.A., Fischel-Ghodsian, N., Puranam, R., Lin, C.P., Marion, M.A. and Attardi,G. (1998) The Deafness-associated mtDNA 7445 mutation, which affects tRNAprecursor processing, has long-range effects on NADH dehydrogenase ND6 subunit gene expression.Mol. Cell. Biol.18:5868-5879.
Guan, M.X,Fischel-Ghodsian, N. and Attardi,G. (2000) A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity.Hum. Mol. Genet. 9: 1787-1793.
Guan, M.X.,Fischel-Ghodsian, N. and Attardi,G. (2001) Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation.Hum. Mol. Genet.10: 573-580.
Li, X., Fischel-Ghodsian,N., Schwartz, F., Yan, Q., Friedman,R.A. and*Guan,M.X.(2004) Biochemical characterization of the mitochondrial tRNAT7511C mutation associated with nonsyndromic deafness.Nucleic Acids Res.32: 867-877.
Zhao, H., Li, R., Wang, Q., Yan, Q., Deng, J.H., Han, D., Bai, Y., Young, W.Y. and*Guan, M.X. (2004) Maternally inherited aminoglycoside-induced and non-syndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family.Am. J. Hum. Genet.74:139-152.
Li, R., Greinwald, J.H., Yang, L., Choo, D.I., Wenstrup, R.J. and*Guan, M.X.(2004) Molecular analysis of mitochondrial 12S rRNA and tRNAgenes in pediatric subjects with nonsyndromic hearing loss.J. Med. Genet. 41:615-620.
Li, Z., Li, R., Chen, J., Liao, Z.,Zhu,Y., Qian,Y., Xiong,S., Heman-Ackah,S., Wu, J., Choo, D.I., and*Guan, M.-X.(2005)Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside induced and non-syndromic hearing loss.Hum. Genet.117:9-15.
Zhao, H., Young, W.Y., Yan, Q., Li, R., Cao, J., Wang, Q., Li, X., Peters, J.L., Han, D., and*Guan, M.X.(2005) Functional characterization of the mitochondrial 12S rRNA C1494T mutation associated with aminoglycoside-induced and nonsyndromic hearing loss.Nucleic Acid Res.33:1132-1139.
*Guan, M.X,Yan, Q., Li, X., Bykhovskaya, Y., J. Gallo-Teran, P. Hajek, N. Umeda, H. Zhao, G. Garrido, E. Mengesha, T.Suzuki, I.del Castillo, J.L. Peters, R. Li, Qian, Y., Wang, X., Ballana, E., M. Shohat, Lu, J., X. Estivill,K. Watanabe, & Fischel-Ghodsian, N. (2006) Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.Am. J. Hum. Genet.79:291-302.
Qian Y,*Guan MX.(2009) Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation.Antimicrob Agents Chemother. 53:4612-4618.
Guan, MX.(2011) Mitochondrial 12S rRNA Mutations associated with aminoglycoside ototoxicity.Mitochondrion11: 237-245.
Yan X, Wang X, Wang Z, Sun S, Chen G, He Y, Mo JQ, Li R, Jiang P, Lin Q, Sun M, Li W, Bai Y, Zhang J, Zhu Y, Lu J, Yan Q, Li H,Guan MX. (2011)Maternally transmitted late-onset non-syndromic deafness is associated with the novel heteroplasmic T12201C mutation in the mitochondrial tRNAgene. J Med Genet. 48:682-90.
Raimundo N, Song, L, Shutt TE, McKay SE, Cotney J,Guan MX, Gilliland TC, Hohuan, D, Santos-Sacchi S, Shadel GS. (2012) Mitochondrial Stress Engages E2F1Apoptotic Signaling to Cause Deafness. Cell. 148, 716-726.
Chen H, Zheng J, Xue L, Meng Y, Wang Y, Zheng B, Fang F, Shi S, Qiu Q, Jiang P, Lu Z, Mo JQ, Lu J,Guan MX. (2012)The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees.Eur J Hum Genet.20(6):607-12.
Zheng J, Ji Y, Guan MX (2012)Mitochondrial tRNA mutations associated with deafness.Mitochondrion. 2012 May;12(3):406-13.
Leber遗传性视神经病变

Qu,J., Li,R., Tong,Y., Zhou,X., Lu,F., Qian,Y., Hu,Y., Mo, J.Q., West, C.E.,*Guan, M.X.(2006) The novel A4435G mutation in the mitochondrial tRNAmay modulate the phenotypic expression of the LHON-associated ND4 G11778A mutation in a Chinese family.Invest. Ophth. Vis. Sci.47:475-83.

Qu, J., Zhou, X., Zhang, J., Zhao, F., Sun, Y.H., Yong, Y., Wei, Q.P., Cai, W., West, C.E. and*Guan, M.X. (2009) Extremely low penetrance of Leber’s hereditary optic neuropathy in eight Han Chinese families carrying the ND4 G11778A mutation.Ophthalmology16:558-564.

Qu J, Wang Y, Tong Y, Zhou X, Zhao F, Yang L, Zhang S, Zhang J, West CE,*Guan MX.(2010)Leber's hereditary optic neuropathy affects only female matrilineal relatives in two Chinese families.Invest Ophthalmol Vis Sci. 51:4906-4912.

Liu XL, Zhou T, Zhou J, Zhao F, Zhang J, Li C, Ji Y, Zhang Y, Wei QP,Sun YH, Yang L, Lin B, Yuan Y, Li Y, Qu J,*Guan MX.(2011) Leber’s hereditary optic neuropathy is associated with the novel T12338C mutation in mitochondrial ND5 gene in six Han Chinese families.Ophthalmology118:.978-985.

原发性高血压

Liu, Y., Li, R., Li, Z., Wang, X., Yang, L., Wang, S.,Guan, M.X.(2009).The mitochondrial tRNA4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree.Hypertension.53:1083-1090.

Li, R., Liu, Y., Li, Z., Yang, L., Wang, S.,Guan, M.X. (2009) Failures in mitochondrial tRNAand tRNAmetabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese family.Hypertension54:329-337.

Wang SW,Li RH, Fettermann A, Li ZB, Qian YP, Liu YQ, Wang XJ, Zhou A, Mo JQ, Yang L, Jiang PP, Taschner A, Rossmanith W,andGuanMX.. (2011) Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAgene in a large Han Chinese family.Circ. Res.108:862-70.

Lu Z, Chen H, Meng Y, Wang Y, Xue L, Zhi S, Qiu Q, Yang L, Mo JQ,*Guan MX. (2011) The tRNA4435A>G mutation in the mitochondrial haplogroup G2a1 is responsible for maternally inherited hypertension in a Chinese pedigree.Eur J Hum Genet. 19(11):1181-6
Qiu Q, Li R, Jiang P, Xue L, Lu Y, Song Y, Han J, Lu Z, Zhi S, Mo JQ, Guan MX. (2012)Mitochondrial tRNA mutations are associated with maternally inherited hypertension in two Han Chinese pedigrees.Hum Mutat. 2012 May 1. doi: 10.1002/humu.22109. [Epub ahead of print]

线粒体tRNA碱基修饰机制

Li, X., Li,R., Lin,X. and*Guan,M.X.(2002) Isolation and characterization of the putative nuclear modifier gene MTO1 involved in the pathogenesis of deafness-associated mitochondrial 12S rRNA A1555G mutation.J. Biol. Chem.277:27256-27264.

Li, X.,*Guan,M.X.(2002) A human mitochondrial GTP binding protein related to tRNA modification may modulate the phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation.Mol. Cell. Biol.22:7701-7711.

Yan, Q., Li, X., Faye, G. and *Guan, M.X. (2005) Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15S rRNA.J. Biol. Chem. 280: 29151-29157.

Guan, M.X,Yan, Q., Li, X., Bykhovskaya, Y., J. Gallo-Teran, P. Hajek, N. Umeda, H. Zhao, G. Garrido, E. Mengesha, T.Suzuki, I.del Castillo, J.L. Peters, R. Li, Qian, Y., Wang, X., Ballana, E., M. Shohat, Lu, J., X. Estivill,K. Watanabe, & Fischel-Ghodsian, N. (2006) Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations.Am. J. Hum. Genet.79:291-302.

Wang X, Yan Q,*Guan MX.(2010) Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNA, tRNA, and tRNAaltered mitochondrial biogenesis and respiration.J Mol Biol.395:1038-1048.

Li R,*Guan MX. (2010) Human mitochondrial leucyl-tRNA synthetase correctes mitochondrial dysfunctions due to the MELAS and diabetes associated tRNAA3243G mutation.Mol Cell Biol. 30:2147-54.

五、联系方式

有意者，请联系郑老师，邮箱：148271673@qq.com

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