一、课题组介绍

秘晓林，博士，教授，博士研究生导师。入选中国科学院“引进国外杰出人才--百人计划”、辽宁省“攀登学者”。国家自然科学基金、国家重大科学研究计划、博士后科学基金、美国国家科学基金研究生项目等评议人，sci杂志international journal of
nanomedicine顾问编委，current proteomics、plos one编委，中国生化药物杂志编委，中国环境诱变剂学会理事，辽宁省医学会医学遗传学分会副主任委员，biomaterials、genetics、international journal of nanomedicine等sci杂志审稿人。主持国家重点基础研
究计划“973”课题、国家自然科学基金项目、中国科学院创新项目等。

1990年毕业于兰州大学生物化学专业，获学士学位；1996年毕业于卫生部兰州生物制品研究所免疫学和微生物学专业，获硕士学位；1999年毕业于中国预防医学科学院病原生物学专业，获博士学位。同年赴美国，在国立卫生研究院（national institutes of health）国
家癌症研究所（national cancer institute）从事博士后研究，随后任职美国国立卫生研究院国家癌症研究所研究学者。作为通讯作者，研究成果发表在proceedings of national academy of sciences usa、plos genetics、oncogene、biomaterials、human
molecular genetics等国际知名学术期刊。

研究方向

1.非编码RNA应答DNA损伤，调节细胞周期、凋亡、转录的功能和机制；

2.肠道干细胞再生与分化的表观遗传调控。

代表性文章（*通讯作者）

1.dai z., li d. *, du x., ge y., hursh d.a., bi x. * drosophila caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. plos genetics. 2020. 16(10):e1009140.  if 5.4

2.li d., liu y., pei c., zhang p., pan l., xiao j., meng s., yuan z., bi x. * mir-285-yki/mask double-negative feedback loop mediates blood-brain barrier integrity in drosophila. proceedings of national academy of sciences usa. 2017. 114(12): e2365-e2374.  if 9.7

3.song f., li d. *, wang y., bi x.* drosophila caliban mediates g1-s transition and ionizing radiation induced s phase checkpoint. cell cycle. 2018. 17(18): 2256-2267.  if 3.3

4.yuan q., tian r., zhao h., li l., bi x. * multiple arginine residues are methylated in drosophila mre11 and required for survival following ionizing radiation. g3: genes genomes genetics. 2018. 8 (6): 2099-2106.  if 2.7

5.li d. and bi x. * effect of teratogens on development of drosophila melanogaster. teratogenicity testing: methods and protocols. methods in molecular biology. springer. 2018. 1797:233-241.

6.cong, w., wang, p., qu, y., tang, j., bai, r., zhao, y., chen, c. *, bi, x. * evalutation of the influence of fullerenol on aging and stress resistance using caenorhabditis elegans. biomaterials. 2015. 42:78-86.  if 8.6

7.jiang k., liu m., lin g., mao b., cheng w., liu h., gal j., zhu h., yuan z., deng w., liu q., gong p., bi x. *, meng s. * tumor suppressor spred2 interaction with lc3 promotes autophagosome maturation and induces autophagy-dependent
cell death. oncotarget. 2016. 7 (18): 25652-25667.  if 5.2

8.chen, h., wang, b., feng, w. *, du, w., ouyang, h., chai, z., bi, x.*  oral magnetite nanoparticles disturb the development of drosophila melanogaster from oogenesis to adult emergence. nanotoxicology. 2015. 9(3):302-312.  if 7.9

9.yuan, q., han, j., cong, w., ge, y., ma, d., dai, z., li, y. *, bi, x. * docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with improved cell apoptosis and gene expression profile and reduced
myelosuppression toxicity. international journal of nanomedicine. 2014.  9(1): 4829-4846.  if 4.3

10.fang, g., zhang, d., yin, h., zheng, l., bi, x.*, yuan, l.*  centlein maintains centrosome cohesion by bridging an interaction between c-nap1 and cep68. journal of cell science. 2014.  127 :1631-1639.  if 5.4

11.wang, y., wang, z., joshi, bh., puri, r., stultz, b., yuan, q., bai, y., zhou, p., yuan, z., hursh, da., bi, x.* the tumor suppressor caliban regulates dna damage induced apoptosis through p53-dependent and ╟independent activity.
oncogene. 2013. 32(33):3857-66.  if 8.6

12.liu, w., jiang, f., bi, x.*, zhang, q*. drosophila fmrp participates in dna damage response by regulating g2/m cell cycle checkpoint and apoptosis. human molecular genetics. 2012, 21(21):4655-68.  if 7.7

13.kong, l., yuan y., zhu, h., li, y., guo, q., zhao, y., wang, q., bi, x.*, gao,x*. the suppression of prostate lncap cancer cells growth by selenium nanoparticles through akt/mdm2/ar controlled apoptosis. biomaterials. 2011.32(27)：
6515-6522.  if 7.6

14.wang, p., bai, y., song, b., wang, y., liu, d., lai, y., bi, x.*, yuan, z*. pp1a-mediated dephosphorylation positively regulates yap2 activity. plos one. 2011.6(9):e24288.  if 4.1

15.gao, g., bi, x., chen, j., srikanta, d., rong, ys. mre11-rad50-nbs complex is required to cap telomeres during drosophila embryogenesis. proceedings of national academy of sciences usa. 2009. 106(26): 10728╟10733.(equal
contribution).  if 9.4

16.bi, x., jones, t., abbasi, f., lee, h., stultz, b., hursh, d., mortin, m. drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. oncogene. 2005. 24:8229-8239.  if 6.8

17.bi, x., srikanta, d., fanti,l., pimpinelli,s., badugu,r., kellum,r., rong, y.s. * drosophila atm and atr checkpoint kinases control partially redundant pathways for telomere maintenance. proceedings of national academy of sciences
usa. 2005. 102(42):15167-15172.  if 10.2

18.bi, x., gong, m., srikanta, d., rong, y.s. * drophila atm and mre11 are essential for the g2/m checkpoint induced by low-dose irradiation. genetics. 2005. 171:845-847.  if 4.4

19.bi, x., wei, s.d., rong, y.s. * telomere protection without a telomerase: the role of atm and mre11 in drosophila telomere maintenance. current biology. 2004. 14:1348-1353.  if 11.9

20.bi, x., kajava, a., demidenko, z., jones, t., mortin, m. * the carboxyl terminus of prospero regulates its subcellular localization.  molecular and cellular  biology.  2003. 23 (3): 1014-1024.  if 8.9

二、招收条件和招生专业

符合我校2021年攻读硕士学位研究生招生简章要求，初试成绩达到全国一类地区硕士研究生初试分数线的普通全日制本科考生。要求生命科学背景，对科研有浓厚兴趣，勤于思考，能够阅读英语专业文献，具备团队精神。

招生院系：医学院。

招生专业：医学生物化学与分子生物学  1001z2。

有攻读博士意向的考生优先考虑。

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